Smarter-SI: Smart well plates for tissue engineering
DescriptionFor cell and tissue culture, it is important to place the cell in a situation that is close to the in vivo case, therefore an adapted support for cell culture is necessary. 500 nm thick Si3N4 membranes with high density of submicron pores, constitute an excellent cell support with an excellent capacity to transport the cell nutriment through the membrane. The cells have the possibility to interact with the medium on both side, a condition close to the in vivo situation. |
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SSI AdvantageThe goal of this project is to develop a smart cell culture insert and multiwell plate for use inside a cell culture incubator using microporous Si3N4 membrane (CSEM building block). The electrodes for TEER measurement are integrated on the membrane and in the inserts that are connected via an interconnection plate and PCB (Ikerlan building block) towards the electronics that will perform sequentially the TEER measurement on the desired well in an automated fashion (Tyndall building block). The data will be collected automatically and will be available via USB connection for analysis. |
Impact & PerspectivesTwo SME partners will benefit directly from the project to a) broaden its portfolio (SIMPLInext) and b) expand its services in complex cell and tissue culture analysis (Vitroscreen). |
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Showcase of Smart System and pictures provided by the SMARTER-SI project: http://www.smarter-si.eu
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